Orgovyx for Advanced Prostate Cancer

Orgovyx is an innovative oral medication for advanced prostate cancer treatment. This blog post aims to provide an overview of Orgovyx, its mechanism, benefits, and considerations for those navigating prostate cancer therapy.

Orgovyx (Relugolix).
Orgovyx (Relugolix) is a treatment option for advanced prostate cancer, functioning as part of the androgen deprivation therapy strategy. Source.

The Role of Testosterone in Prostate Cancer

Testosterone, the primary male sex hormone, plays a pivotal role in the growth and spread of prostate cancer cells. Androgen deprivation therapy (ADT) is a cornerstone in treating advanced prostate cancer, aimed at reducing testosterone levels in the body. Traditional ADT methods include surgery (orchiectomy), testosterone-blocking injections, and pills. Orgovyx is another approach in this context.

Orgovyx and ADT

Orgovyx belongs to a class of drugs known as gonadotropin-releasing hormone (GnRH) receptor antagonists. It operates by blocking the GnRH receptor, thus inhibiting the release of hormones that stimulate testosterone production. This results in a significant reduction of testosterone levels, essential in combating prostate cancer.

FDA and EMA Approval of Orgovyx

The approval of Orgovyx by the FDA in 2020 and the EMA in 2021 underscores its effectiveness and safety in treating advanced prostate cancer. Notably, it is the first oral medication providing ADT without the need for injections, marking a significant advancement in treatment accessibility and patient comfort.

Clinical Trial Insights of Orgovyx

Clinical trials have demonstrated the proficiency of Orgovyx in rapidly reducing testosterone levels to castration levels in over 90% of patients within just four days of initiation. It also showed superiority in improving survival outcomes and reducing tumor progression compared to traditional leuprolide injections.

Navigating Orgovyx's Side Effects

While Orgovyx is effective, it is not without side effects. These can include hot flashes, fatigue, gastrointestinal disturbances, weight changes, gynecomastia, sexual health changes, and potential heart rhythm abnormalities. It is important for patients to be aware of these potential side effects and discuss them with their healthcare provider.

Dosage and Administration of Orgivyx

Orgovyx is administered orally, with a recommended initial dose of 360 mg, followed by a daily dose of 120 mg. Patients are advised not to stop or alter the medication without consulting their doctor, as it can lead to a rebound in testosterone levels.

Suitability and Precautions of Orgovyx

Orgovyx is not suitable for everyone. It is contraindicated in women, children, and individuals with allergies to its components. Caution is advised for patients with heart, bleeding, diabetic, liver, or kidney conditions. It is crucial for patients to inform their healthcare providers about all medications they are taking, as Orgovyx can interact with various drugs, potentially altering its effectiveness or leading to adverse effects.


Orgovyx is a new option for people with advanced prostate cancer who need androgen deprivation therapy or ADT. It offers the convenience of oral administration and avoids the pain and inconvenience of injections. It also has similar or better effectiveness and safety than leuprolide injections. However, Orgovyx still has some side effects and interactions that need to be monitored by a doctor. If you have advanced prostate cancer and are interested in Orgovyx, talk to your doctor about whether it is right for you.

Disclaimer: This blog post is intended solely for informational purposes. It is not meant to serve as medical advice. For professional medical guidance, please consult your doctor.

Further Reading

  1. Shore ND, Saad F, Cookson MS et al. Oral Relugolix for Androgen-Deprivation Therapy in Advanced Prostate Cancer. N Engl J Med 2020;382:2187-96.
  2. Shore ND, Saad F, Cookson MS et al. HERO phase III trial: Results comparing relugolix, an oral GnRH receptor antagonist versus leuprolide acetate for advanced prostate cancer [abstract]. J Clin Oncol 2020;38(suppl):5602.
  3. Orgovyx: Side Effects, Cost, Use for Prostate Cancer, and More. Healthline. (accessed Nov 29, 2023).
  4. Orgovyx: Dosage, side effects, uses, interactions, and more. Medical News Today. (accessed Nov 29, 2023).
  5. Orgovyx | European Medicines Agency. (accessed Nov 29, 2023).


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